Several factors can cause a reduction in estrogen, such as breastfeeding, cigarette smoking, depression, excessive stress, immune system disorders, surgery to remove the ovaries, and radiation therapy. It is usually caused by decreasing estrogen levels, a hormone that helps lubricate vaginal tissues. Vaginal dryness is not a symptom of any sexually transmitted disease (STD). Treatments for vaginal dryness vary depending on the cause and may include lubricants and moisturizers to reduce irritation and discomfort during sex. Symptoms of vaginal dryness include burning and itching, bleeding after intercourse, soreness in the vulva, pain or discomfort during penetrative sex, light bleeding after intercourse, mild vaginal discharge, and needing to urinate more often than usual. Hormonal changes can also cause dryness due to decreased estrogen levels, which can happen during menopause or the years leading up to it. Insufficient arousal can be caused by inadequate foreplay or psychological issues that prevent a woman from becoming aroused. It can be caused by a few factors, including insufficient arousal and hormonal changes. Vaginal dryness after sex is a common problem for many women. Additionally, some women find relief from using coconut oil, Vaseline, or olive oil as a moisturizer. Treatments for vaginal dryness during sex include using lubricants and vaginal moisturizing creams to help moisten the area for several hours up to a day. Other causes include cigarette smoking, depression, too much stress, immune system disorders like Sjögren syndrome, and childbirth. Estrogen is a hormone that helps keep the vaginal tissue healthy by maintaining normal lubrication. Vaginal dryness during sex can be caused by various factors, including reduced estrogen levels, breastfeeding, certain medications, and menopause.
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His penchant for dad joke punchlines, familial details, general grandiosity and, yes, numbskull comments about women is still intact. The Life Of Pablo is a stark reminder that while his music and production has developed over time - he is, perhaps, the only pop radio artist who has released an album that might as well have come out on Tri Angle - Kanye hasn’t, at least not lyrically. To even consider how Dame and Kanye have essentially switched roles is to realize how much can evolve in a decade and change. He just has much more fame, access and cachet than he did as a Roc-A-Fella producer being given a shot for impressing Dame Dash with lines like, “Mayonnaise-colored Benz / I push miracle whips”. People do not lose their core personality, which means West has not lost his, either. It is certainly self-aware, capping the track off with a giggling nod to the meme “I love you like Kanye loves Kanye”, but there is also so much to unpack in under a minute. On the a cappella ‘I Love Kanye’ he raps about nostalgia for pink-Polo-and-soul-sample Kanye and the sneering at “bad mood Kanye / Spazz in the news Kanye”. His awareness of these critiques does not go unacknowledged. It’s no wonder Kanye is so pissed when people accusing him of ranting, or pokes fun at his own perceived aggressiveness: as much as the public cares to judge him, he is always inspecting himself under an even stronger microscope. With ‘FML’, The Weeknd sings on the hook, “Even though I always fuck my life / Only I can mention me.” It’s a mantra of self-reflection, subtly mirroring the idea that only God can judge, and demands an insurmountable count of honesty in so few words. But Pablo is also a gospel album by less obvious means. There are parts that are readily comprehensible as part of that genre: the choir who pad out opener ‘Ultralight Beam’ and the leads sung by Kelly Price, Terius “The-Dream” Nash and gospel icon Kirk Franklin the four-year old rebuking the devil sampled from Instagram elemental lifts from Chicago pastor T.L Barrett’s ‘Father I Stretch My Hands’. “As much as the public cares to judge him, Kanye is always inspecting himself under an even stronger microscope.”īefore its release, West proclaimed this a gospel album. But despite how much of it is predicated on Kanye Talking About Kanye, it is also supposed to act as a credo that guides his listener to see themselves the way he sees himself. His seventh studio album The Life of Pablo is once more an album full of self-awareness. He’s the same man who issued an enormous public apology with My Beautiful Dark Twisted Fantasy, after becoming public enemy number one in the wake of his mother’s death. ‘Can’t Tell Me Nothing’, the lead single from Graduation, felt patently un-Kanye in the context of his first two albums, but foretold the man we’ve seen unfold over the past ten years. He vetted his place on The College Dropout with a makeshift résumé on ‘Spaceship’ (“Lock yourself in a room doing nine beats a day for three summers”) and slammed the notion that rapping about faith was a foolish idea on ‘Jesus Walks’. He has been hammering home that understanding his beliefs has been paramount to him from the very start. His interest is not as shallow as this sounds. Since his 2004 debut, there has been no one else more concerned with the public perception of Kanye West than Kanye West. If you gave a child a stuffed toy to take to bed at night, that had an electronic box that made soothing sounds-like a ticking, or a gentle breeze, or ocean noises-you would talk about "soothing" or "calming" the child. A person who said they were "hypnotizing" their children would be regarded as strange. No, people do not talk about "hypnotizing" babies. "I was completely mesmerized by Cirque du Soleil." "I was completely hypnotized by the sunset and did not realize I had been watching it for half an hour, until I started to get cold."Ī person who has been hypnotized is said to be in a "trance," and you could call the sunset "entrancing." We think of nothing but what we are seeing. In the figurative meaning, refer to something, such as a performance, or a natural wonder, that draws our attention so strongly that we forget where we are. You might say "I am going to see a hypnotherapist to see if he can help me lose weight." You would never say "I am going to see a mesmerist." It was named for Franz Mesmer, 1734-1815. Research suggests it was first coined in the early 19th century by Étienne Félix d’Henin de. When you use transformational hypnotherapy with the right understanding, you are literally rewiring your brain. In any event, the actual, literal phenomenon is called "hypnotism." The term hypnosis is derived from the Ancient Greek word for sleep (hypnos). Hypnosis is a unique tool that puts you in contact with the source of your subconscious programming (the thoughts, memories, beliefs, and emotions that shape you). Psychologists who study it prefer the term "hypnosis" to "hypnotism," and when it is used as a legitimate medical treatment "hypnotherapy" and "hypnotherapist" are preferred to "hypnotism" and "hypnotist." The word "hypnotized" is used today, in a straightforward and literal way. "Mesmerize" is an out-of-date word for "hypnotize." There is no difference in meaning, as far as I know. © 2023 Hookshot Media, partner of ReedPop. 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The method falls under supervised learning and requires categories of sites as input.Ī sequence-order independent algorithm for binding site comparison. Similarity exercise is performed through alignment of hash tables.Ī binding site is encapsulated in a 3D voxel-grid which is passed through a convolutional neural network to map to a vector descriptor. It is a geometric hashing based comparison technique, hashes pairs of residues, taken from input structures into a 3D hash table based on residue types and distances from geometric centers. Table 1. Brief descriptions of methods for binding site comparison.īinding sites are aligned based on matching residue groups between sites and carrying out site alignment. A brief description of these methods is provided in (table 1). Several methods have come till date for the purpose of binding site comparison. Alignment dependent methods provide detailed information on the atomic mapping of protein structures where as alignment free methods output a similarity score. There are two types of site comparison methods: alignment-dependent methods and alignment-free methods. However for scaling to handle thousands of features originating in data such as medical texts, protein function, pathway information and other sources, deep learning methodologies have come into the picture. Traditional machine learning methodologies over the last two decades require careful feature engineering and sometimes involve hand crafted features and atomic motifs. This volume of data has enabled use of machine learning methodology for comparison of protein–ligand binding sites. Today about 167 000- high-quality protein structures are available in the Protein Data Bank. The structure of a protein is determined through a variety of means including experimental mechanisms such as x-ray crystallography or nuclear magnetic resonance and analytical methods such as sequence or structural alignment to known structures. Ī main source for structure of a binding site is the structure of its protein in terms of the 3D coordinates of all of its thousands of atoms. Binding site comparison is one of the major methods in the field of structural bioinformatics and drug discovery. A major reason for functional similarity between proteins is the similarity of their binding sites and hence interaction patterns with ligand molecules. One protein may have a dozen concavities and some of which may be functional resulting in moonlighting behaviour. Electrostatic and chemical complimentarity, aromatic stacking and other forms of interactions between atoms of a concavity and a ligand molecule result in chemical binding. A binding site is a concavity on the surface of a protein, composed of several amino acids whose side chains interact with a ligand molecule. Protein–ligand interaction plays an important role in biological systems. We also provide the method as a standalone executable and a web service hosted at ().Ī protein performs its function by interacting with ligands and other small molecules. The algorithm serves for high throughput processing and has been evaluated for stability with respect to reference frame shifts, coordinate perturbations and residue mutations. The method has been the top performer with more than 95% quality scores in extensive benchmarking studies carried over 10 data sets and against 23 other site comparison methods in the field. The vector embedding serves as a locality sensitive hash function for proximity queries and determining similar sites. The method is based on pairwise distances between representative points and chemical compositions in terms of constituent amino acids of a site. We report here a novel algorithm, Site2Vec, that derives reference frame invariant vector embedding of a protein–ligand binding site. However, one fundamental challenge in applying deep learning to structures of binding sites is the input representation and the reference frame. In this regard, deep neural network algorithms are now deployed which can capture very complex input feature space. Traditional methods based on hand engineered motifs and atomic configurations are not scalable across several thousands of sites. Machine learning methods for similarity assessment require feature descriptors of binding sites. To this end, methods for computing similarities between binding sites are still evolving and is an active area of research even today. Tasks such as assessment of protein functional similarity and detection of side effects of drugs need identification of similar binding sites of disparate proteins across diverse pathways. Binding sites would also determine ADMET properties of a drug molecule. Ligands are small molecules that interact with protein molecules at specific regions on their surfaces called binding sites. Protein–ligand interactions are one of the fundamental types of molecular interactions in living systems. Javascript can be output with a simple parameter. Javascript has an impact on what the user sees on the site. You should be able to focus on the code and we will take care of data aggregation. The web scraping API doesn't require additional headers. Chrome browser is used in headless mode to display your website exactly the same way it would in a browser. You can work without worrying about blocking and headaches. We'll send you the URL you want and return an HTML response. 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